Existing Nanomedicines

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Clinically approved nanomedicines and nanoformulations

 

 

Nanomaterial API Brand name Company Approved
Polymer-protein conjugate Adenosine Deaminase Adagen® Sigma-Tau Pharmaceuticals/ Enzon 1990 (USA)
Micelle Paclitaxel Taxol® Bristol Myres Squibb 1992 (USA)
Polymer-protein conjugate Asparaginase Oncasper® Enzon 1994 (USA)
Liposome Amphotericin B Abelcet® Sigma-Tau Pharmaceuticals 1995 (USA)
Liposome Doxorubicin Caelyx® Centocor Ortho Biotech/ Janssen Biotech 1995 (USA), 1996 (EU)
Micelle Docetaxel Taxotere® Sanofi-Aventis 1995 (EU), 1996 (USA)
Polymeric drug Glatiramer acetate Copaxone® Teva 1996 (USA)
Liposome Daunorubicin citrate DaunoXome® NeXstar Phamaceuticals/ Gilead 1996 (USA)
SPION (diagnostic) n/a Endorem® Guerbet/ Amag Pharmaceuticals 1996 (USA)
SPION (diagnostic) n/a GastroMARK® Guerbet/ Amag Pharmaceuticals 1996 (USA/EU)
Liposome Amphoteracin B Ambisome® Astellas Pharma/ Gilead 1997 (USA)
Virosome Vaccine Inflexal® V Berna Biotech/ Crucell 1997 (USA)
Liposome Cytarabine Depocyt® Pacira Pharms/ Sigma-Tau Pharmaceuticals 1999 (USA), 2001 (EU)
Sodium ferric gluconate complex Iron supplement Ferrlecit® Sanofi-Aventis 1999 (USA)
Nanocrystal Sirolimus Rapamune® Wyeth Pharm/ Pfizer 1999 (USA), 2001 (EU)
Liposome Doxorubicin Myocet® Sopherion Therapeutics/ Cephalon 2000 (EU)
Polymer-protein conjugate IFN-α2b PEGINTRON® Schering Plough 2000 (EU), 2001 (USA)
Polymeric drug Sevelamer HCl Renagel® Genzyme 2000 (USA/EU)
Iron oxide glucose complex Iron supplement Venofer® Fresenius/ Luipold 2000 (USA)
Liposome Verteporfin Visudyne® Novartis 2000 (USA/EU)
Polymeric drug Colesevelam HCl Welchol® Daiichi Sankyo 2000 (USA)
SPION (diagnostic) n/a Resovist® Bayer Schering Pharma 2001 (EU)
Polymer-protein conjugate PEGfilgrastim Neulasta® Amgen 2002 (USA/EU)
Polymer-protein conjugate IFN-α2a PEGASYS® Hoffmann-LaRoche 2002 (USA/EU)
Polymer-protein conjugate PEGvisomant Somavert® Pfizer 2002 (EU), 2003 (USA)
Nanocrystal Aprepitant Emend® Merck 2003 (USA/EU)
Micelle Estradiol hemihydrate Estraorb™ Novavax/ Graceway 2003 (USA)
Liposome Morphine sulphate Depodur® EKR Therapeutics 2004 (USA)
Polymer-aptamer conjugate siRNA Macugen® Eyetech 2004 (USA), 2006 (EU)
Nanocrystal Fenofibrate Tricor® Abbott 2004 (USA)
Albumin nanoparticle Paclitaxel Abraxane® Abraxis Bioscience/ Celgene Europe 2005 (USA), 2008 (EU)
Nanocrystal Megestrol acetate Megace® EC Par Pharmaceuticals 2005 (USA)
Nanocrystal Fenofibrate Triglide® SkyePharma/ First Horizon 2005 (USA)
Polymer-protein conjugate Epoetin β Mircera® Hoffmann-LaRoche 2007 (USA/EU)
Polymer-protein conjugate Anti-TNF-α Cimzia® Nektar 2008 (USA), 2009 (EU)
SPION (diagnostic) n/a Feraheme® Amag Pharmaceuticals/ Takeda 2009 (USA)
Liposome Mifamurtide Mepact® IDM Pharma 2009 (EU)
Polymer-protein conjugate Urate oxidase Krystexxa® Savient Pharmaceuticals 2010 (USA)
Nanoemulsion Dexpanthenol Bepanthen® spray Bayer On market
Virosome Vaccine Epaxal® Berna Biotech/ Crucell On market
Virosome Vaccine Influvac® Plus Solvay Pharma/ Abbott On market
Albumin nanoparticle Radiodiagnostic (99mTc) Nanocoll® GE Healthcare On market
Gold nanoparticle (diagnostic) n/a Verigene® Nanosphere On market
Liposome Vincristine sulphate Marqibo® Inex/ Enzon/ Thanlon Therapeutics On market (2012)